Advantages: The genomic big data in the Internet is conducive to the discovery of massive potential products; the automated high-throughput production platform, which replaces manpower with machinery, greatly speeds up the mining of products.
Background: Studies have shown that 90% of the natural drug resources are still hidden in the seabed and have not been developed, while the efficiency of the classical discovery methods of natural drugs is getting lower and lower.
Success case: The team has screened 227 PTTS genes from 476 genome-sequenced filamentous fungi and NCBI and UniProt databases. Using the self-developed high-efficiency terpenoid precursor supplied Saccharomyces cerevisiae as the chassis and combined with a high-throughput automated platform, the functions of 34 new PTTSs were successfully identified, more than double the number of all known PTTSs.
English
